High Resolution MR Spectroscopy Reveals Radiation Induced Metabolic Changes in Mouse Liver Tissues

Introduction: Liver is considered to be a highly radio-resistant organ on the criterion of morphological changes, radiation hepatitis and radiation necrosis of the liver. However, whole body radiation exposure may induce a variety of additional effects that can be expressed at cellular and tissue levels like generation of oxidative stress, alteration in gene transcription or changes in signal transduction, which ultimately has cumulative effect on the metabolic status of cell or tissue. High resolution H NMR spectroscopy is established as a tool for investigating the metabolic consequences of drug as well as environmental toxicity. Therefore, present study has been planned to use NMR spectroscopy technique to uncover metabolic response of liver in mice when exposed to a moderate dose of ionising radiation.